drug discovery
Revolutionizing the Small Molecule Drug Discovery Process
Our unique drug discovery process aims to address the burden of disease on society by efficiently discovering new chemical entities or identifying new uses for existing chemical entities that can interrupt key proteins in disease pathways.
How we do it
Our Process
01
Ideation and Simulation
Our drug discovery process begins with our proprietary in silico methodology. We use AI, Quantum Chemistry, Biochemistry, and Computer Vision to predict and construct organic compounds that can directly or allosterically interrupt proteins in biological pathways. We have combined all these techniques into one unified purpose-built platform called BioTD Sim. This makes us one of the few select teams in the world capable of discovering new small molecule drugs in silico using AI and quantum chemistry.
02
Synthesis and In Vitro Assays
We then confirm our in silico results through in vitro assays. We use various assays such as FRET, ITC, SPR, antiviral assays using Huh7 cells, activity assays using HEK293 cells, and complement cascade assays to test the biological activity of the compounds.
03
Iteration and Optimization
Based on the results of the in vitro assays, we iterate and optimize the compounds using derivative molecules. This helps us refine the compounds and increase their effectiveness.
04
In Vivo Confirmation
Once we have a promising compound, we confirm the results through in vivo small animal models, usually murine models. We use predefined statistical analysis on multiple applicable endpoints to ensure that the compound is effective and safe for use.
05
First in Human Trials
If the results of the in vivo testing are positive, we take candidate drugs to First in Human (FIH) trials. These trials are the first stage of clinical trials where the drug is given to humans to determine its safety, dosage, and potential side effects. Before a drug can enter FIH trials, it must be approved by regulatory authorities through an Investigational New Drug (IND) application. Our commitment to this rigorous process ensures that our drugs are safe and effective for human use.
